10 Incredible and amazing Facts About your own body: The Human Genome

There are between 30,000 and 40,000 genes in the human genome. Some previous estimates suggested there could be 100,000 or more human genes.
There are between 30,000 and 40,000 genes in the human genome. Some previous estimates suggested there could be 100,000 or more human genes.

Genetic sequencing information is providing more evidence of how we diverged from monkeys 25 million years ago. What genetics is also clearly showing is our close relationship with other life forms. In the words of John Sulston: “We are confirming Darwin – that is the most useful take-home message from this. It is the unity of life, or Nature being conservative, or the idea of the Blind Watchmaker – the notion of evolution as a constant reworking or random recombining of parts.”

DNA or deoxyribonucleic acid codes for your genetic make-up. These make human genomes. There are lots of facts about human genomes, but here are 10 that are particularly interesting, important, or fun.

series of DNA makes the human genome

1) There are between 30,000 and 40,000 genes in the human genome. Some previous estimates suggested there could be 100,000 or more human genes.

2) A human being can be made from a gene count only twice as great as that of a fly or worm. There are 26,000 genes in the plant thale cress; 18,000 in the nematode worm; 13,000 in a fruit fly, 6,000 in yeast, and 4,000 in the tuberculosis microbe.

3) We are not fruit flies or worms because some of our genes work differently – we have more “control genes.”

As we trace the increase of complexity from single cell creatures, through small animals like worms and flies, and up to us, what we appear to be adding is control genes. Evolution is not so much adding new genes performing wholly new functions – what it’s chiefly doing is to increase the variety and subtlety of genes that control other genes.

It contains thousands of Base pairs
It contains thousands of Basepairs

4) Hundreds of genes appear to have come from bacteria – one of which has been associated with depression.

We don’t understand the mechanism of transfer, and indeed it’s possible that the bacteria have picked up our genes rather than the other way round – though this seems less likely. But either way, it’s a tremendous reminder of the unity of life, and of the fact that we don’t live in a cocoon isolated from other species.

5) Most mutations occur in males. It’s about a two-fold difference. One suggested reason is the larger number of cell divisions in the male germ line (sperm).

6) More than one million SNPs have been identified.

Looking at the genetic differences between people – one variation every 500 to 1,000 bases (letters) – will usher in a new era of personalised medicine. Currently, more than 1.4 million of these variations, known as SNPs (single nucleotide polymorphisms) have been found. Overall, humans are 99.8% genetically similar.

7)The purpose of the 97% of “junk” DNA is being discovered.

We have got stronger hints than before that the repeat family called Alu may play some important function. We have always suspected that we couldn’t simply divide the genome into 3% of good stuff (genes) and 97% of junk. Here we are beginning to see some of the functions of the ‘junk’. Exactly as one would expect the junk has a function – rather more diffuse than the hard information carried by the genes, but nevertheless functional in some way. It may help to move genes around.

8) Just 483 existing “targets” in the body account for all the pharmaceutical drugs on the market.

The HGP and the SNPs research will provide thousands of extra “doorways” or destinations for new medicines and drugs to work on. Already new ways of tackling asthma, Alzheimer’s disease and depression are being looked at, using new genetic targets.

It looks like a computer programme
It looks like a computer programme

9) Understanding how the body works is dramatically increasing due to HGP knowledge.

Apart from new drugs, the HGP research is pointing to a vastly increased knowledge of how the human body works – with better explanations now available for a range of conditions or biological responses.
One small example is that the mystery of bitter taste has been solved – a new family of proteins (which come from genes) that control this response have been found in taste buds.

10) Understanding of how we evolved as human beings are being rapidly advanced through “genetic archaeology.”

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